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Kazuhiko Watabe Selected Research

T 588

7/2007A novel drug therapy for recurrent laryngeal nerve injury using T-588.
12/2005Peripheral nerve avulsion injuries as experimental models for adult motoneuron degeneration.
6/2003Oral administration of a neuroprotective compound T-588 prevents motoneuron degeneration after facial nerve avulsion in adult rats.

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Kazuhiko Watabe Research Topics

Disease

8Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
06/2022 - 03/2006
4Facial Nerve Injuries
02/2011 - 04/2003
3Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar)
06/2022 - 01/2017
3Coinfection
06/2022 - 02/2014
3Sarcoma (Soft Tissue Sarcoma)
06/2022 - 02/2014
3Diabetic Neuropathies (Diabetic Neuropathy)
01/2018 - 07/2006
3Recurrent Laryngeal Nerve Injuries
07/2007 - 02/2003
3Motor Neuron Disease (Primary Lateral Sclerosis)
12/2005 - 04/2003
2Neurodegenerative Diseases (Neurodegenerative Disease)
06/2022 - 03/2006
2Polyneuropathies (Polyneuropathy)
01/2021 - 07/2015
2Stroke (Strokes)
08/2014 - 04/2003
2Globoid Cell Leukodystrophy (Krabbe Disease)
04/2005 - 06/2002
2Demyelinating Diseases (Demyelinating Disease)
04/2005 - 06/2002
1Parkinson Disease (Parkinson's Disease)
06/2022
1Familial Amyloid Neuropathies (Familial Amyloid Polyneuropathy)
01/2021
1Starvation
11/2017
1Type C Niemann-Pick Disease (Niemann Pick Disease, Type C)
11/2017
1Peripheral Nervous System Diseases (PNS Diseases)
01/2016
1Amyloid Plaque
07/2015
1Amyloidosis
07/2015
1B-Cell Lymphoma (Lymphoma, B Cell)
03/2015
1Infarction (Infarctions)
08/2014
1Brain Ischemia (Cerebral Ischemia)
08/2014
1Hyperglycemia
09/2011
1Insulin Resistance
09/2011
1Alzheimer Disease (Alzheimer's Disease)
01/2010
1Neuroblastoma
01/2010
1Glioma (Gliomas)
01/2010
1Pathologic Processes
12/2009
1Retrograde Degeneration
02/2008
1Dementia (Dementias)
09/2007
1Paralysis (Palsy)
07/2007
1Peripheral Nerve Injuries
07/2007
1Diabetes Complications
05/2007
1Vocal Cord Paralysis
02/2007
1Crush Injuries
02/2007
1Stab Wounds (Stab Wound)
03/2006
1Brain Injuries (Brain Injury)
03/2006

Drug/Important Bio-Agent (IBA)

7Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
07/2007 - 02/2003
5DNA-Binding Proteins (DNA Binding Protein)IBA
06/2022 - 02/2014
4Brain-Derived Neurotrophic Factor (BDNF)IBA
07/2007 - 04/2003
3polyolIBA
01/2018 - 07/2006
3Glucose (Dextrose)FDA LinkGeneric
01/2018 - 07/2006
3T 588IBA
07/2007 - 06/2003
2Heat Shock Transcription FactorsIBA
06/2022 - 12/2020
2Proteins (Proteins, Gene)FDA Link
06/2022 - 11/2017
2Superoxide Dismutase-1IBA
06/2022 - 10/2005
2Prealbumin (Transthyretin)IBA
01/2021 - 07/2015
2Glutamic Acid (Glutamate)FDA Link
12/2020 - 04/2020
2CalciumIBA
01/2010 - 12/2009
2GalactosylceramidaseIBA
04/2005 - 06/2002
1Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA
06/2022
1Protein AggregatesIBA
06/2022
1polyglutamineIBA
06/2022
1Ataxin-3IBA
06/2022
1SynucleinsIBA
06/2022
1Proteasome Endopeptidase Complex (Proteasome)IBA
06/2022
1Ligases (Synthetase)IBA
12/2020
1UbiquitinIBA
12/2020
1Cystine (L-Cystine)IBA
12/2020
1AntiportersIBA
12/2020
1IronIBA
04/2020
1Aldehyde Reductase (Aldose Reductase)IBA
01/2018
1Leucine (L-Leucine)FDA Link
11/2017
1Amiodarone (Amiodarona)FDA LinkGeneric
01/2016
1Anti-Arrhythmia AgentsIBA
01/2016
1Superoxide DismutaseIBA
01/2016
1ZincIBA
01/2016
1CopperIBA
01/2016
14-hydroxy-2-nonenal (4-hydroxynonenal)IBA
03/2015
1SootIBA
08/2014
1SuspensionsIBA
08/2014
1Mannitol (Osmitrol)FDA LinkGeneric
08/2014
1salicylhydroxamic acid (SHAM)IBA
08/2014
1Small Interfering RNA (siRNA)IBA
02/2014
1Insulin (Novolin)FDA Link
09/2011
1Nerve Growth Factors (Neurotrophins)IBA
01/2011
1TunicamycinIBA
01/2010
1Phospholipases (Phospholipase)IBA
12/2009
1Calcium-Independent Phospholipases A2IBA
12/2009
1RNA (Ribonucleic Acid)IBA
02/2008
1beta-SynucleinIBA
09/2007
1Insulin-Like PeptidesIBA
07/2007
1Insulin-Like Growth Factor I (IGF-1)IBA
07/2007
1Pyruvaldehyde (Methylglyoxal)IBA
05/2007
1Advanced Glycation End ProductsIBA
05/2007
1Reactive Oxygen Species (Oxygen Radicals)IBA
05/2007
1Therapeutic UsesIBA
02/2007
1Metallothionein 3IBA
03/2006
1MetallothioneinIBA
03/2006
1Bovine Serum AlbuminIBA
01/2006
1mannose-6-phosphateIBA
01/2006

Therapy/Procedure

3Oral Administration
07/2007 - 06/2003
2Therapeutics
09/2011 - 01/2005
1Gastrostomy
01/2016
1Tracheostomy
01/2015
1Mechanical Ventilators (Ventilator)
09/2011
1Axotomy
02/2011
1Drug Therapy (Chemotherapy)
07/2007
1Enzyme Replacement Therapy
01/2006